After completing his MSc in Biomedicine at Lancaster University, George went on to study Clinical Neuroscience at the University of Cambridge. During his MPhil course, George worked with Dr Andras Lakatos studying different stem cell derived spinal neurons and astrocytes. In 2019, George started his Clinical Neuroscience PhD in Dr Andras Lakatos' lab, funded by Spinal Research. His research focuses on utilising human systems to model cortico-spinal circuity.
Why neuroscience research in spinal cord injury is important to George
"Therapeutic interventions for Spinal Cord Injury are currently lacking. This can leave patients with poor motor outcomes despite high costs and investments in rehabilitation programs. To better develop strategies to improve treatments for SCI, further understanding is required into the molecular and cellular mechanisms at play. Bridging previous work from rodent models, with novel stem cell derived human models, should aid in discovery of new therapeutic targets and mechanisms with the aim of further developing greater treatment options for patients."
Working with Organoids
Organoids are self-organized three-dimensional tissue cultures that are derived from stem cells. Their advantage over cells in a two-dimensional space, such as in a petri dish, is that the three-dimensional structure reflects the environment of an animal model more accurately, and therefore the effect of treatments translates to animal or clinical studies more faithfully.
On the 28th April - 1st May 2022, George presented his work on the topic of organoids at the American Society for Neural Therapy & Repair (ASNTR) meeting in Clearwater Beach, Florida.